Lenka Henao Misikova

PDGFD-induced pericyte contractility drives pathological neoangiogenesis

This study identifies PDGFD-ROCK-NMIIA signaling in pericytes as a driver of pathological neoangiogenesis in retinopathies, revealing cell-type-specific actomyosin contractility mechanisms.

Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential

This study perturbs LINE-1 elements in mouse embryonic stem cells to show their cis-regulatory impact on gene expression, with 1,024 genes misregulated upon activation and 81 upon repression.

Competition for endothelial cell polarity drives vascular morphogenesis

The paper shows that competition between biochemical and mechanical cues regulates endothelial cell polarity, driving vascular morphogenesis through tension shifts.