Claudio Areias Franco

This study identifies PDGFD-ROCK-NMIIA signaling in pericytes as a driver of pathological neoangiogenesis in retinopathies, revealing cell-type-specific actomyosin contractility mechanisms.

This paper develops a 3D tumor-on-a-chip platform to study and test drugs that block breast cancer cell intravasation, showing that Dactolisib reduces intravasation without harming endothelial cells.

3DVascNet is a deep learning-based software that segments and quantifies 3D vascular networks, showing high performance and generalization across datasets and organs.

The paper uses Cell Painting images to preselect compounds for drug screening, significantly increasing hit rates by reducing the number of compounds tested.

The paper identifies cell type-specific alternative splicing changes in lung development, particularly in Vegfa, that may prepare the lung for postnatal function.

The paper shows that competition between biochemical and mechanical cues regulates endothelial cell polarity, driving vascular morphogenesis through tension shifts.

This paper demonstrates the feasibility of 3D/4D light-sheet fluorescence microscopy for imaging mouse retinal pathology, revealing new features in the OIR model and highlighting distorted morphology from flat-mounting.

PolNet quantifies endothelial cell polarity and blood flow in vascular networks using image analysis and computational fluid dynamics.

This study shows YAP and TAZ regulate endothelial cell dynamics and vascular development by modulating junctions and signaling pathways.