Ectopic engraftment of nociceptive neurons derived from hPSCs for pain relief and joint homeostasis
Zhuolun Wang, Weixin Zhang, Ju Wang, Zhiping Wu, Xu Cao, Junmin Peng, Gabsang Lee, Xinzhong Dong
This paper demonstrates that transplanting CD200-high hPSC-derived nociceptors reduces pain and promotes joint repair in osteoarthritis by acting as decoys for inflammatory ligands and secreting reparative factors.
bioRxiv · Dec 19, 2025 · PreprintNeuroscience