Zhiping Wu

The paper identifies LRRC57/RABIN as a presynaptic inhibitor of Rab GTPases in glutamatergic neurons, showing it regulates neurotransmitter release and prevents epileptiform activity.

This study identifies MRGPRX4 as a melanoma driver that promotes invasion, therapy resistance, and an immunosuppressive tumor microenvironment.

This study identifies HOIL-1 as an atypical E3 ligase that protects the ribosome during nutrient stress, revealing a new signaling pathway involved in cell fate decisions.

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

This paper demonstrates that transplanting CD200-high hPSC-derived nociceptors reduces pain and promotes joint repair in osteoarthritis by acting as decoys for inflammatory ligands and secreting reparative factors.

This study identifies AKAP11 as a critical autophagy receptor linking PKA kinase network regulation to synaptic transmission, with loss-of-function impacting pathways associated with bipolar disorder and schizophrenia.

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

This study quantifies protein expression in rat brains, identifies pQTLs, and links them to behavioral traits and human disorders.

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

This study uses proteomic profiling of intracranial atherosclerotic plaques to identify differentially expressed proteins associated with ICAD, revealing potential biomarkers and biological pathways involved in the disease.