SANDRO JOSÉ DE SOUZA

GTX-GUT: A Standardized Metagenomic Workflow for Gut Microbiome Profiling and Clinical Associations

GTX-GUT is a standardized metagenomic workflow for gut microbiome profiling that integrates quality control, taxonomic classification, and clinical association analysis, showing improved accuracy and reproducibility in microbiome studies.

Developmental Dysregulation of Synaptic and Myelin-Related Genes in Frontal Cortex and Serum Infrared Spectroscopy Signature in the Valproic Acid Model of Autism

This study investigates molecular changes in the frontal cortex and serum of VPA-exposed rats, finding dysregulated myelin and synaptic genes and a serum FTIR spectroscopy biomarker for autism.

Detecting predicted cancer-testis antigens in proteomics datasets of healthy and tumoral samples

The paper analyzes proteomics data to identify cancer-testis antigens (CTAs) in healthy and tumor tissues, finding 22 significantly enriched, 42 tumor-exclusive, and 32 healthy-abundant CTAs.

A new genome-wide method to identify genes with bimodal gene expression

The paper introduces a method to detect bimodal gene expression using Gaussian Mixture Models and identifies 554 bimodal genes across 25 tumor types, with 96 linked to prognosis differences.

Characterization and analysis of the transcriptome in Arapaima gigas using multi-tissue RNA-sequencing

The paper characterizes the transcriptome of Arapaima gigas using multi-tissue RNA-sequencing to identify tissue-specific and sex-biased gene expression patterns.

neoANT-HILL: an integrated tool for identification of potential neoantigens

neoANT-HILL improves neoantigen detection from NGS data by integrating immunogenomic analyses and was tested on melanoma TCGA somatic mutations.

On the impact of the pangenome and annotation discrepancies while building protein sequence databases for bacteria proteogenomics

The paper evaluates how merging multiple bacterial strains into protein sequence databases affects proteogenomics by analyzing pangenome complexity and annotation discrepancies.