Ândrea Ribeiro‐dos‐Santos

SlytheRINs compares conformational changes in proteins by analyzing residue interaction networks across multiple structures to identify dynamic shifts linked to functional impacts.

The paper introduces mtDNA-Network, a tool for analyzing mitochondrial variants in admixed Brazilian populations with complex diseases.

The paper identifies mitochondrial variants associated with Parkinson's disease in Brazilians and develops a polygenic risk score linked to increased disease risk.

This study identifies ANPEP as upregulated in gastric adenocarcinoma and associated with immune suppression and tumor progression, suggesting its potential as a biomarker and therapeutic target.

This study identifies mitochondrial DNA variants associated with levodopa responsiveness in Parkinson's disease patients, highlighting specific subunit mutations and population-specific variants.

The paper fine-tunes the Enformer model using synthetic regulatory sequences to improve its predictive performance on non-reference sequences.

The paper identifies context-dependent enhancer synergy in mouse embryonic stem cells, showing that enhancers can significantly boost neighboring DHS activity and that this synergy depends on distance and specific transcription factor sequences.

The paper investigates how genomic context affects enhancer function by analyzing the murine Igf2/H19 locus and shows that regulatory elements depend on their native surroundings.

This paper introduces mSwAP-In, a method for efficient genome rewriting in mouse embryonic stem cells, demonstrating its use for Trp53 and ACE2 locus modifications to create more accurate disease models.

The paper uses synthetic regulatory genomics to study Sox2 expression in mESCs, finding that some enhancer regions are context-dependent and can enhance core regulatory elements.

The paper analyzes microbial community changes in Amazon mangroves along a highway, finding biodiversity loss in impacted areas.

The paper investigates how genomic context affects CTCF insulator function by analyzing reporter activity across various genomic configurations.

The paper investigates ACE2 polymorphisms in South American and global populations to explain sex and ancestry-related differences in COVID-19 outcomes.

The paper characterizes the transcriptome of Arapaima gigas using multi-tissue RNA-sequencing to identify tissue-specific and sex-biased gene expression patterns.

The paper investigates TMPRSS2 genetic variation in East Asian and European populations to assess its role in susceptibility and outcomes of COVID-19.