Gustavo A. de Souza

GTX-GUT: A Standardized Metagenomic Workflow for Gut Microbiome Profiling and Clinical Associations

GTX-GUT is a standardized metagenomic workflow for gut microbiome profiling that integrates quality control, taxonomic classification, and clinical association analysis, showing improved accuracy and reproducibility in microbiome studies.

From Data Curation to Risk Reporting: A Pipeline for Polygenic Risk Scores

This paper presents a pipeline for polygenic risk score calculation that includes data curation, statistical methods, and reporting, resulting in a curated database and interpretable reports for PRS analysis.

SlytheRINs: using graph parameters and residue interaction networks to analyze protein dynamics and structural ensembles

SlytheRINs compares conformational changes in proteins by analyzing residue interaction networks across multiple structures to identify dynamic shifts linked to functional impacts.

Intrinsically disordered insert from SH2D2A rewires CD19 CAR signaling via Tyr290

This study identifies a specific tyrosine residue in an intrinsically disordered SH2D2A sequence that rewires CD19 CAR signaling and surface expression.

Beyond the Shared Inflammatory Axis: Differentiating Molecular Signatures in Psoriatic Arthritis and Ankylosing Spondylitis through Integrated Omics

This study compares transcriptomic signatures of psoriatic arthritis and ankylosing spondylitis to identify shared and distinct molecular features using integrative omics approaches.

Detecting predicted cancer-testis antigens in proteomics datasets of healthy and tumoral samples

The paper analyzes proteomics data to identify cancer-testis antigens (CTAs) in healthy and tumor tissues, finding 22 significantly enriched, 42 tumor-exclusive, and 32 healthy-abundant CTAs.

A novel approach to identify cross-identity peptides between Epstein-Barr virus and central nervous system proteins in Guillain-Barre syndrome and multiple sclerosis

The paper identifies cross-identity peptides between Epstein-Barr virus and central nervous system proteins using computational methods, suggesting molecular mimicry and potential autoantigen cross-reactivity.

EpitoCore: mining conserved epitope vaccine candidates in the core proteome of multiple bacteria strains

EpitoCore identifies conserved epitopes in bacterial core proteomes across multiple strains to prioritize vaccine candidates.

On the impact of the pangenome and annotation discrepancies while building protein sequence databases for bacteria proteogenomics

The paper evaluates how merging multiple bacterial strains into protein sequence databases affects proteogenomics by analyzing pangenome complexity and annotation discrepancies.