Crucial role for iron metabolism in mediating influenza A virus infection and associated disease
Amber L. Pillar, Katie Daly, Henry M. Gomez, Ama‐Tawiah Essilfie, Kai Sen Tan, Jing Liu, Anand Kumar Andiappan, Alexandra C Brown, Richard Kim, Kristy Nichol, Chantal Donovan, Gregory Jon Anderson, Andreas Suhrbier, David Michael Frazer, Elizabeth A. Milward, , Jemma Mayall
This study shows that iron metabolism influences influenza A virus infection and disease by altering gene expression, increasing viral titer, and worsening inflammation, with TFR1 inhibition offering protection.
bioRxiv · Mar 20, 2025 · PreprintImmunology