Cancer BiologybioRxivPreprint
Hypoxia-activated prodrug and chemotherapy disrupt resistance-associated metabolism in osteosarcoma
Sophie M. Pearce, Neil Alan Cross, Lucy Flint…·Laura M. Cole
This study shows that combining hypoxia-activated prodrugs with chemotherapy disrupts metabolic resistance mechanisms in osteosarcoma by targeting ferroptosis, glycolysis, and survival pathways.
DOI 10.64898/2026.06.16.732534