Author

Lucy Flint

AstraZeneca (United Kingdom)ORCID 0000-0001-6187-3081Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Gregory R. HammiD· 2 shared Heather HulmeiD· 2 shared Aleksandr ZakiroviD· 1 shared Alix Le MaroisiD· 1 shared Ana C. CunhaiD· 1 shared Andrea SerioiD· 1 shared Andrew RiddelliD· 1 shared Anne-Marie FortieriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Gregory R. HammORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 18, 2026

Hypoxia-activated prodrug and chemotherapy disrupt resistance-associated metabolism in osteosarcoma

Sophie M. Pearce, Neil Alan Cross, Lucy Flint…·Laura M. Cole

This study shows that combining hypoxia-activated prodrugs with chemotherapy disrupts metabolic resistance mechanisms in osteosarcoma by targeting ferroptosis, glycolysis, and survival pathways.

DOI 10.64898/2026.06.16.732534

humanmetabolomics

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BioinformaticsbioRxivPreprintApr 29, 2026

SMEW: An interactive multi-scale toolkit for cross-condition and network-based analysis of spatial metabolomics data

Eleanor C Williams, Heather Hulme, Aleksandr Zakirov…·Irina Mohorianu

SMEW provides a code-free, interactive platform for analyzing spatial metabolomics data across multiple scales and conditions to identify metabolic patterns and biological pathways.

DOI 10.64898/2026.04.27.721059

mousemetabolomics

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Cancer BiologybioRxivPreprintJun 6, 2025

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

Colin D.H. Ratcliffe, Hugh Sparks, Giulia L. M. Boezio…·Erik A. Sahai

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.

DOI 10.1101/2025.06.06.658331

humanorganoid / primary culture

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