Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancer
Ameet Ajit Chimote, Abdulaziz O. Alshwimi, Simran Venkatraman, Jay Bhati, Maria A. Lehn, Somchai Chutipongtanate, Sarmistha Das, Susan Kasper, Shesh Nath Rai, Scott M. Langevin, Trisha Michel Wise-Draper, Laura Conforti
This study identifies KCa3.1 channels as a target for enhancing immune responses in HNSCC by showing exosomes suppress CD8 T cell function through Ca2+ signaling disruption.
bioRxiv · Jul 25, 2025 · PreprintImmunology