Shesh Nath Rai

Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eμ-TCL1 mice

This study shows that a high-fat Western diet accelerates CLL progression and alters gut microbiome composition in Eμ-TCL1 mice.

PTPN11 Mutation Clonal Hierarchy in Acute Myeloid Leukemia

This study identifies PTPN11 mutations as potential initiating events in AML when paired with NPM1 mutations, revealing their co-driver role and immune diversity in patient samples.

Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancer

This study identifies KCa3.1 channels as a target for enhancing immune responses in HNSCC by showing exosomes suppress CD8 T cell function through Ca2+ signaling disruption.

Multiomics reveals the genomic, proteomic and metabolic influences of histidyl dipeptides on heart

This study uses multiomics to show histidyl dipeptides regulate heart function by altering microRNAs, proteins, and metabolites involved in fatty acid oxidation and the TCA cycle.

Inferring metabolite interactomes via molecular structure informed Bayesian graphical model selection with an application to coronary artery disease

The paper develops a Bayesian graphical model to infer metabolite interactomes using molecular structure information and applies it to coronary artery disease data.

Evaluation Of Classifier Performance For Multiclass Phenotype Discrimination In Untargeted Metabolomics

The paper evaluates classifier performance for multiclass phenotype discrimination in untargeted metabolomics using simulated and real data, finding that SVM and Random Forest outperform PLS-DA and Neural Networks in most scenarios.