Kārlis Pleiko

The paper investigates how disruptions at different positions in the de novo purine biosynthesis pathway in yeast affect cellular responses to purine starvation.

The paper develops a proximity labeling method to identify vascular homing peptide receptors on live cells, demonstrating its effectiveness with RPARPAR and NRP-1.

This paper demonstrates that the GreenB1 aptamer specifically targets β1-integrin in triple-negative breast cancer cells and tumors, suggesting its potential for precision diagnosis and therapy.

IgemRNA is a transcriptome analysis tool that integrates genome-scale metabolic modeling, offering pre-processing, analysis, and visualization with a graphical interface.

The paper introduces a method to identify organ-specific peptides using differential binding analysis of in vivo phage display data, improving the efficiency and reproducibility of biopanning.

The paper introduces a differential binding cell-SELEX method using HTS to identify cell-specific aptamers, demonstrating improved selection rates against live cells.