Tambet Teesalu

Brain-specific PP1/LRRK2 interaction-targeting peptides as a novel strategy for Parkinson's disease treatment

The paper develops a peptide, PEP 3, that disrupts the LRRK2/PP1 interaction and shows promise as a therapeutic for Parkinson's disease by reducing dopaminergic cell death and alpha-synuclein phosphorylation.

Proximity labelling-based identification of vascular homing peptide receptors

The paper develops a proximity labeling method to identify vascular homing peptide receptors on live cells, demonstrating its effectiveness with RPARPAR and NRP-1.

Therapeutic Tumor Macrophage Reprogramming in Breast Cancer Through a Peptide-Drug Conjugate

This paper develops a peptide-drug conjugate, MACTIDE-V, that reprograms tumor-associated macrophages in breast cancer, reducing metastasis and enhancing anti-tumor immunity.

A CYCLIC PEPTIDE TARGETS GLIOBLASTOMA BY BINDING TO ABERRANTLY EXPOSED SNAP25

This paper identifies a cyclic peptide, CES, that targets glioblastoma by binding to aberrantly exposed SNAP25, showing its potential as a drug delivery tool and molecular marker.

Targeting triple-negative breast cancer with β1-integrin binding aptamer

This paper demonstrates that the GreenB1 aptamer specifically targets β1-integrin in triple-negative breast cancer cells and tumors, suggesting its potential for precision diagnosis and therapy.

In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues

The paper introduces a method to identify organ-specific peptides using differential binding analysis of in vivo phage display data, improving the efficiency and reproducibility of biopanning.