Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release TRKB from inhibitory control without changing perineuronal nets enwrapping parvalbumin interneurons
Cecilia Cannarozzo, Anna Rubiolo, Plinio Cabrera Casarotto, Eero Ċastrén
This study shows ketamine and its metabolite R,R-HNK enhance ocular dominance plasticity by releasing TRKB from PTPσ inhibition without altering PNNs.
bioRxiv · Apr 6, 2022 · PreprintNeuroscience