Cecilia Cannarozzo

This study shows that a TRKB mutation blocking antidepressant binding does not affect BDNF-stimulated activation or baseline TRKB function, but impairs antidepressant responses.

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

This study shows ketamine and its metabolite R,R-HNK enhance ocular dominance plasticity by releasing TRKB from PTPσ inhibition without altering PNNs.

The paper identifies CRAC and CARC motifs in RTK transmembrane domains, showing cholesterol interaction with TRKB's CARC motif and its effect on BDNF binding.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

This study shows that fluoxetine can extend ocular dominance plasticity in adult mice beyond the natural critical period, but the effect stops when the drug is discontinued.