Eero Ċastrén

Low-dimensional brain-symptom associations delineate depression phenotypes with distinct connectivity biomarkers and symptom profiles

The paper identifies five distinct depression phenotypes using MEG-oscillation functional connectivity and low-dimensional brain-symptom associations.

Surgical Protocol for a Large, Resealable Cranial Window Enabling Longitudinal, Multi-Modal Electrophysiology Recordings of the Mouse Default Mode Network

This paper describes a surgical protocol for creating a large, resealable cranial window in mice to enable long-term, multi-modal electrophysiological recordings of the Default Mode Network.

Fingolimod acutely facilitates the activation of TRKB

This study shows that fingolimod acutely activates TRKB through BDNF-dependent mechanisms, enhancing neuronal plasticity and normalizing fear responses in BDNF-deficient mice.

Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples

This study investigates TrkB-FL cleavage and TrkB-ICD formation during epileptogenesis in a rat model and human samples, finding a correlation with seizure severity and memory impairment.

Chronic treatment with fluoxetine downregulates mitochondrial activity in parvalbumin interneurons of prefrontal cortex

This study shows chronic fluoxetine reduces mitochondrial activity in parvalbumin interneurons of the prefrontal cortex, potentially leading to disinhibition and enhanced synaptic plasticity.

The BDNF/TrkB pathway in Somatostatin-expressing neurons suppresses cocaine-seeking behaviour

This study shows that TrkB-mediated plasticity in Somatostatin-expressing neurons is critical for the extinction of cocaine-seeking behavior and preventing relapse.

Mutation in the TRKB cholesterol recognition site that blocks antidepressant binding does not influence the basal or BDNF-stimulated activation of TRKB

This study shows that a TRKB mutation blocking antidepressant binding does not affect BDNF-stimulated activation or baseline TRKB function, but impairs antidepressant responses.

Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants

This study shows that TrkB activation in PV+ interneurons is essential for antidepressant-induced behavioral flexibility and synaptic plasticity in spatial and fear memory.

Nitric oxide-induced tyrosine nitration of TrkB impairs BDNF signaling and restrains neuronal plasticity

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release TRKB from inhibitory control without changing perineuronal nets enwrapping parvalbumin interneurons

This study shows ketamine and its metabolite R,R-HNK enhance ocular dominance plasticity by releasing TRKB from PTPσ inhibition without altering PNNs.

SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression

This study shows SorCS2 deficiency worsens Huntington's disease in mice by disrupting BDNF signaling and NMDA receptor function in striatal neurons.

Perineuronal net receptor PTPσ regulates retention of memories

This study shows that reduced PTPσ expression improves short-term memory but impairs long-term memory retention in mice, suggesting PTPσ's role in memory retention through TRKB signaling.

Cholesterol recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: the case for TRKB

The paper identifies CRAC and CARC motifs in RTK transmembrane domains, showing cholesterol interaction with TRKB's CARC motif and its effect on BDNF binding.

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction

The paper uses optogenetics to activate TrkB receptors in the ventral hippocampus, enhancing plasticity and improving fear extinction in mice.

Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

This study shows that FTY720 treatment after symptom onset in an AD mouse model improves synaptic and memory deficits through anti-inflammatory effects.

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.

Culturing primary neurons from rat hippocampus and cortex

This paper describes a reliable protocol for culturing primary neurons from rat hippocampus and cortex with minimal non-neuronal contamination, enabling long-term maintenance and differentiation.

Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors

This study shows anandamide activates TRKB through CB1 and TRPV1 receptors, influencing neuronal migration and behavior in rat cortical cells.

Neurotrophin Receptor Ntrk2b Function In The Maintenance Of Dopamine And Serotonin Neurons In Zebrafish

This study investigates the role of Ntrk2b in maintaining dopamine and serotonin neurons in zebrafish, showing its specific impact on these aminergic systems.

Temporal patterns of fluoxetine-induced plasticity in the mouse visual cortex

This study shows that fluoxetine can extend ocular dominance plasticity in adult mice beyond the natural critical period, but the effect stops when the drug is discontinued.

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

This study shows that isoflurane anesthesia produces antidepressant-like effects in rodents by activating TrkB signaling and related molecular pathways.