Plinio Cabrera Casarotto

This study shows that fingolimod acutely activates TRKB through BDNF-dependent mechanisms, enhancing neuronal plasticity and normalizing fear responses in BDNF-deficient mice.

This study shows that a TRKB mutation blocking antidepressant binding does not affect BDNF-stimulated activation or baseline TRKB function, but impairs antidepressant responses.

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

This study shows ketamine and its metabolite R,R-HNK enhance ocular dominance plasticity by releasing TRKB from PTPσ inhibition without altering PNNs.

This study shows SorCS2 deficiency worsens Huntington's disease in mice by disrupting BDNF signaling and NMDA receptor function in striatal neurons.

This study shows that reduced PTPσ expression improves short-term memory but impairs long-term memory retention in mice, suggesting PTPσ's role in memory retention through TRKB signaling.

The paper identifies CRAC and CARC motifs in RTK transmembrane domains, showing cholesterol interaction with TRKB's CARC motif and its effect on BDNF binding.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

This study shows that FTY720 treatment after symptom onset in an AD mouse model improves synaptic and memory deficits through anti-inflammatory effects.

The paper shows that repeated aminoguanidine administration increases TRKB phosphorylation in the dPAG, which is necessary for its panicolytic-like effect in rats.

This study shows anandamide activates TRKB through CB1 and TRPV1 receptors, influencing neuronal migration and behavior in rat cortical cells.

This study shows that isoflurane anesthesia produces antidepressant-like effects in rodents by activating TrkB signaling and related molecular pathways.

This study shows that the antidepressant-like effect of PPADS depends on serotonergic and noradrenergic systems, as its effect is blocked by depleting these systems.