Cleavage region organizes the structural architecture of the B2 SINE ribozyme
Ankush Singhal, Tyler Mrozowich, Carlos Rivera-López, Susmitnarayan Chaudhury, Lilei Xu, Rodrigo Aguilar, Maulik D. Badmalia, Jeannie T. Lee, Trushar R. Patel, Karissa Y. Sanbonmatsu
The paper determines the structural ensemble-to-function relations of the B2 SINE ribozyme using RNA chemical probing, X-ray scattering, and modeling, showing cleavage site dependency on its structure and function.
Communications Biology · Mar 23, 2026Peer-reviewedBiophysics