Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction
Luhong Wang, Charlotte Vanacker, Laura L. Burger, Tammy M. Barnes, Yatrik Madhukar Shah, Martin Grosvenor Myers, Suzanne M. Moenter
This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.
eLife · Apr 4, 2019Peer-reviewedNeuroscience