Yatrik Madhukar Shah

Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers

This study identifies Abi-1-S323 phosphorylation as a biomarker for DNA repair states and treatment response in cancers, showing its role in regulating radiosensitivity through Rac1 and CHK1 signaling.

Hydrogen sulfide dynamically upregulates copper uptake and localization

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a (Hif1a) during postnatal development

This study shows that the postnatal tendon enthesis remains hypoxic and requires Hif1a for cell survival, ECM organization, and structural integrity.

Engineering tumor-homing bacteria as membrane-anchored immune checkpoint-blockade interfaces

This paper engineers tumor-homing bacteria to display immune checkpoint-blocking nanobodies, showing enhanced tumor suppression in mouse models compared to traditional antibody therapies.

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

Targeting HIF-2α in Colorectal Cancer Reveals a Cholesterol Biosynthesis-Dependent Ferroptotic Vulnerability

This study identifies a metabolic vulnerability in colorectal cancer where combining HIF-2 inhibition with cholesterol biosynthesis inhibition using statins enhances ferroptosis, offering a new therapeutic strategy.

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

Genetically induced mouse model for colon-specific epithelial cell tumorigenesis driven by loss of K8 and Apc

This study develops a genetic, colon-specific mouse model of colorectal cancer driven by K8 and Apc loss, showing increased tumorigenesis and reduced K8 expression in human patients.

Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

Programmable conjugative CRISPR interference targeting genotoxin in the gut

This paper develops a CRISPRi system to suppress colibactin production in pks E. coli, reducing DNA damage and tumorigenesis in mice.

Myoglobin leaching into the serum of IDA mice is driven by the high activation of sGC under anemic conditions which induces myoglobin expression

This study shows that myoglobin leaks into the serum of anemic mice due to increased sGC activation and expression, which is linked to iron deficiency anemia.

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

Aspartate transaminases are required for blood development

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

Hydrogen sulfide increases intracellular oxygen and regulates the HIF response

This study shows hydrogen sulfide increases intracellular oxygen and destabilizes HIF-1, altering hypoxia sensing and potentially contributing to O2 toxicity diseases.

Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors.

This study shows glucose metabolism sustains STAT3 activation in colorectal cancer through glycosylated paracrine factors, identifying a potential therapeutic target.

Labile iron pool dynamics do not drive ferroptosis potentiation in colorectal cancer cells

This study investigates the role of labile iron pool dynamics in ferroptosis in colorectal cancer cells and finds that exogenous iron supplementation reduces cell viability without measurable LIP expansion during ferroptosis.

Gut sulfide metabolism modulates behavior and brain bioenergetics

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

H2S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes

This study shows that chronic hydrogen sulfide exposure alters mitochondrial structure and function in human cells by disrupting cristae and respiratory supercomplexes.

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma

This study identifies SLC4A11 as a mediator of ammonia import in hepatocellular carcinoma, showing its role in promoting cancer stemness and tumor growth.

A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK.

This study shows that C. elegans fed oxidative stress-adapted bacteria live longer and are more stress-resistant due to activation of the p38-MAPK pathway.

Structural enrichment attenuates colitis-associated colon cancer

The paper investigates how enriched versus impoverished housing conditions affect tumorigenesis in a mouse model of colitis-associated colon cancer, finding enriched housing reduces tumor burden.

Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.