Martin Grosvenor Myers

This study identifies a single dorsal vagal complex circuit that mediates both aversive and anorectic responses to GLP1R agonists, showing that APGlp1r neurons are responsible for both effects.

The paper identifies distinct AP neuron subtypes that respond to different macronutrients and physiological signals, revealing their roles in satiety and homeostasis beyond nausea.

The paper identifies distinct subpopulations of LeprGlp1r neurons that separately control food intake and blood pressure.

The paper identifies VMNCckbr neurons that regulate fasting blood glucose by enhancing adipose tissue lipolysis and substrate release via the sympathetic nervous system.

This study shows that neuronal SEL1L-HRD1 ERAD is critical for one-carbon metabolism, motor function, and survival, with loss leading to severe neurological defects.

The paper creates a cross-species atlas of the dorsal vagal complex using single-nucleus RNA sequencing and spatial profiling, revealing molecular mechanisms of cagrilintide's effects on energy balance.

This study shows that glutamatergic signaling from leptin-responsive PMv neurons is essential for puberty and reproductive function in female mice.

The paper identifies synergistic effects of multiple NTS neuron populations in suppressing food intake but shows they are not essential for the response to vertical sleeve gastrectomy.

The paper identifies a conserved population of GABAergic Glp1r-expressing LepRb neurons that mediate leptin's suppression of food intake and prevention of obesity.

The paper identifies conserved VMH neuron populations across species using TRAP-seq and snRNA-seq data, defining six major neuron classes with distinct anatomical and genetic features.

This study identifies GFRAL-expressing neurons in the hindbrain that suppress food intake through aversive pathways by responding to non-meal-related signals.

This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.