Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells
Roxane Verdikt, Abigail A. Armstrong, Jenny Yeuk‐Ki Cheng, Young Sun Hwang, Amander T. Clark, Xia Yang, Patrick Allard
This study shows that Δ9-THC exposure increases proliferation of naive mouse ESCs through CB1 receptor activation, with metabolic changes retained during differentiation to primordial germ cell-like cells.
eLife · Dec 27, 2023Peer-reviewedDevelopmental Biology