Patrick Allard

The paper introduces a cell village-based fitness screening approach and a Dirichlet regression framework to analyze genetic factors affecting cell proliferation and environmental sensitivity in human neural progenitor cells.

This study shows that newer insecticides like flupyradifurone cause dopaminergic neurodegeneration in C. elegans, marked by dendritic blebbing and oxidative stress, which can be mitigated by antioxidants or genetic interventions.

The paper evaluates yeast and nematode high-throughput assays for identifying reproductive toxic environmental chemicals and finds moderate to strong correlations with mammalian in vivo data.

The paper screens 133 chemicals for reproductive toxicity using C. elegans assays and compares results with ToxCast data, identifying 13 toxicants including QACs.

This study shows that Δ9-THC exposure increases proliferation of naive mouse ESCs through CB1 receptor activation, with metabolic changes retained during differentiation to primordial germ cell-like cells.

This study uses single-nucleus RNA-seq to map the adult C. elegans transcriptome and assess inter- and trans-generational effects of alcohol exposure at cell type resolution.

The paper identifies de novo variants in EIF2AK1 and EIF2AK2 associated with neurodevelopmental disorders and leukoencephalopathy, showing similar pathogenic mechanisms to CACH/VWM.

This study investigates prenatal Bisphenol A exposure in mice, identifying multi-tissue omics disruptions linked to cardiometabolic disorders.

This study identifies damaging variants in IRF2BPL associated with neurological phenotypes in humans and shows functional conservation in fruit flies.