Amander T. Clark

The paper screens human cortical organoids with small molecules to identify translational modulators affecting progenitor progression in corticogenesis, finding Emetine promotes neuronal differentiation.

The paper investigates the cell and molecular origins of the primate ovarian reserve using rhesus macaques, identifying PG2 cells as the primary source of primordial follicles and describing the recruitment of fetal theca cells for hormone production.

The paper shows that TFAP2A+ progenitor cells generate amnion, germline, and mesoderm through BMP signaling and basement membrane cues in vitro.

The paper introduces scMHT-seq, a single-cell method to profile 5mC, 5hmC, and transcriptomes, revealing DNA methylation erasure mechanisms in human primordial germ cell maturation.

This study shows that Δ9-THC exposure increases proliferation of naive mouse ESCs through CB1 receptor activation, with metabolic changes retained during differentiation to primordial germ cell-like cells.

This study shows that maintaining human pluripotent stem cells with feeders improves cortical organoid formation by activating TGFβ signaling and naive pluripotency genes, which can be mimicked with TGFβ growth factors.

This study validates the differentiation of rhesus macaque primordial germ cell-like cells (rPGCLCs) using transplantation into adult gonadal niches, showing they commit to late PGCs and spermatogonia-like cells but not ENO2-positive spermatogonia.