Dual Targeting for Enhanced Tumor Immunity: Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid-Driven T-Cell Activation
Thomas Thisted, F. Donelson Smith, Zhi-Gang Jiang, Zuzana Biesová, Adejumoke M. Onumajuru, Yuliya Kleschenko, Kanam Malhotra, Vikas Saxena, Arnab Mukherjee, Edward Htun van der Horst
This paper develops pH-selective CD28xVISTA bispecific antibodies that enhance T-cell activation in the tumor microenvironment while minimizing systemic side effects.
bioRxiv · Apr 7, 2025 · PreprintCancer Biology