Cancer BiologybioRxivPreprint
Dual Targeting for Enhanced Tumor Immunity: Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid-Driven T-Cell Activation
Thomas Thisted, F. Donelson Smith, Zhi-Gang Jiang…·Edward Htun van der Horst
This paper develops pH-selective CD28xVISTA bispecific antibodies that enhance T-cell activation in the tumor microenvironment while minimizing systemic side effects.