Nucleotide State Regulates Asymmetric Substrate-Binding Protein Docking in a Type II ABC Importer
Alexandra Karagiaridi, Ramon Mendoza Uriarte, Muyuan Chen, Benoı̂t Roux, Heather W. Pinkett
This study determines the structural changes in a Type II ABC importer's substrate-binding protein in different nucleotide states, revealing how ATP binding and hydrolysis regulate its conformation and interaction with the transporter.
bioRxiv · Oct 16, 2026 · PreprintBiochemistry