Author

Ramon Mendoza Uriarte

University of ChicagoORCID 0000-0002-2917-945XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Benoı̂t RouxiD· 2 shared Alexandra KaragiaridiiD· 1 shared Bernardo I. PintoiD· 1 shared Eduardo PerozoiD· 1 shared Francisco BezanillaiD· 1 shared Heather W. PinkettiD· 1 shared Lydia BlachowicziD· 1 shared Muyuan CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Benoı̂t RouxORCID

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2 papers

Recent·Most cited

Nucleotide State Regulates Asymmetric Substrate-Binding Protein Docking in a Type II ABC Importer

Alexandra Karagiaridi, Ramon Mendoza Uriarte, Muyuan Chen, Benoı̂t Roux, Heather W. Pinkett

This study determines the structural changes in a Type II ABC importer's substrate-binding protein in different nucleotide states, revealing how ATP binding and hydrolysis regulate its conformation and interaction with the transporter.

bioRxiv · Oct 16, 2026 · PreprintBiochemistry

Structure of the ILT Mutant Shaker K+ Channel and the Mechanism of Voltage Activation

Richa Agrawal, Ramon Mendoza Uriarte, Bernardo I. Pinto, Trayder Thomas, Lydia Blachowicz, Young Hoon Koh, Francisco Bezanilla, Eduardo Perozo, Benoı̂t Roux

The paper determines the cryo-EM structure of a Shaker K+ channel mutant and shows that voltage sensing domain activation induces a dynamic shift in the linker population equilibrium rather than directly pulling the gate open.

bioRxiv · Nov 13, 2025 · PreprintBiophysics