Shaina P. Cahill

The dentate gyrus grows throughout life despite turnover of developmentally-born neurons

The paper quantifies neuronal birth and loss in the rat dentate gyrus across adulthood, finding that neurogenesis contributes to growth but is offset by neuronal turnover.

Adult-born hippocampal neurons undergo extended development and are morphologically distinct from neonatally-born neurons

The paper examines the development and morphology of adult-born neurons in rats, finding they mature over months and have distinct features compared to neonatally-born neurons, contributing to hippocampal plasticity into old age.

Dentate gyrus neurons that are born at the peak of development, but not before or after, die in adulthood

The paper shows that neurons born at the peak of development in the dentate gyrus die later in adulthood, while neurons born before or after are stable.

A combination of running and memantine increases neurogenesis and reduces activation of developmentally-born dentate granule neurons in rats

This study shows that increasing adult neurogenesis in rats reduces activity in developmentally-born dentate granule neurons, supporting an inhibitory role for new neurons in hippocampal function.

Differential effects of extended exercise and memantine treatment on adult neurogenesis in male and female rats

This study examines the long-term effects of exercise and memantine on adult neurogenesis in male and female rats, finding sex-specific differences in treatment efficacy.

Early survival and delayed death of developmentally-born dentate gyrus neurons

This study examines the survival and maturation of developmentally-born dentate gyrus neurons, finding they survive early but experience delayed death later, with implications for memory and neurological disorders.

Running Promotes Spatial Bias Independently Of Adult Neurogenesis

This study shows that running promotes spatial navigation strategies in mice, even when adult neurogenesis is blocked, suggesting exercise enhances cognitive flexibility independently of neurogenesis.