Paul W. Frankland

Delayed maturation of hippocampal trisynaptic circuitry underlies the protracted development of episodic-like memory

This study shows that delayed maturation of trisynaptic hippocampal circuitry is essential for the development of high-resolution episodic-like memory in mice.

Latent dentate gyrus engrams formed in infancy scaffold adult learning

The paper shows that infant-formed engrams persist as latent memories in mice and support adult learning through reactivation of dentate gyrus ensembles.

Activity-dependent myelination in prefrontal circuits signals the offset of infantile amnesia

The paper shows that activity in the prelimbic cortex of developing mice promotes myelination and memory persistence, delaying infantile amnesia when inhibited.

Whole-brain analyses identify anterior cingulate μ-opioid signaling as a critical mediator of placebo analgesia in neuropathic pain

This study identifies anterior cingulate μ-opioid signaling as critical for placebo analgesia in neuropathic pain using whole-brain network analysis in mice.

Distinct CA1 inputs support shifts in neural dimensionality and memory resolution

The paper shows that distinct inputs to the CA1 region of the hippocampus support different memory resolutions by altering neural dimensionality and feedforward inhibition.

Neurogenesis-dependent transformation of hippocampal memory traces during systems consolidation

The paper shows that hippocampal memory resolution decreases over time, and this transformation depends on adult hippocampal neurogenesis.

A sensitive period for the development of episodic-like memory in mice

This study shows that early-life experiences during a sensitive period influence the timing of episodic-like memory development in mice by modulating perineuronal net formation.

Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence.

This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.

Autism-associated PTCHD1 missense variants bind to the SNARE-associated protein, SNAPIN, but exhibit impaired subcellular trafficking

The paper identifies a novel interaction between PTCHD1 and SNAPIN and shows that some missense variants impair subcellular trafficking without affecting binding.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Genetic variants in DDX53 contribute to Autism Spectrum Disorder associated with the Xp22.11 locus

The paper identifies DDX53 genetic variants in individuals with ASD, showing a link between DDX53 and ASD, and highlights implications for genetic testing and mouse modeling.

Single cell approaches define forebrain neural stem cell niches and identify microglial ligands that enhance precursor-mediated remyelination

The paper uses single-cell RNA-sequencing and spatial transcriptomics to study forebrain neural stem cell niches and identifies microglial ligands that enhance remyelination.

Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability

This paper investigates how nonsynonymous mutations in PTCHD1 affect protein stability and N-glycosylation, showing disrupted glycosylation processing but normal localization and interaction with SAP102.

Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.

A shift in the mechanisms controlling hippocampal engram formation during brain maturation

This study shows that the maturation of hippocampal inhibitory interneurons by extracellular matrix is necessary for the development of precise episodic-like memories in mice.

Evolution of predictive memory in the hippocampus

This study shows how hippocampal activity supports building predictive models by organizing newly learned information according to its congruence with existing memories.

Alcohol dependence modifies brain networks activated during abstinence and reaccess: a c-fos-based analysis in mice

The paper uses c-fos mapping and network analysis to show that alcohol dependence alters brain network activity during abstinence and reaccess in mice, with increased network modularity in high-drinking mice after reaccess.

Can neurogenesis act as a neural regularizer?

This paper investigates whether neurogenesis acts as a regularizer in neural networks, finding it enhances generalization in a category learning task.

Why do hippocampal mossy cells matter? It depends on the frequency and context.

This study shows mossy cells influence hippocampal function differently based on frequency and context, affecting memory and seizure risk.

AZBA: A 3D Adult Zebrafish Brain Atlas for the Digital Age

The paper introduces AZBA, a 3D adult zebrafish brain atlas created using tissue clearing and imaging techniques, providing a detailed segmentation of over 200 neuroanatomical regions.

Learning to be on time: temporal coordination of neural dynamics by activity-dependent myelination

The paper introduces an Activity-Dependent Myelination (ADM) rule that optimizes neural synchrony by adjusting conduction velocity based on firing rates and axonal length variability.

Automated curation of CNMF-E-extracted ROI spatial footprints and calcium traces using open-source AutoML tools

The paper introduces an automated curation method for CNMF-E-extracted ROIs and calcium traces using TPOT and AutoSklearn, achieving an F1 score > 92% on a test dataset.

Changes in the functional connectome and behavior after exposure to chronic stress and increasing neurogenesis

This study investigates how increased adult hippocampal neurogenesis affects stress-related behavior and brain network connectivity in mice exposed to chronic stress.

Genetic and behavioural requirements for structural brain plasticity

The paper investigates how environmental enrichment affects brain volume in mice and identifies molecular processes involved, showing CREB is not required for these changes.

A compact head-mounted endoscope for in vivo calcium imaging in freely-behaving mice

This paper describes the construction and use of a low-cost, open-source head-mounted endoscope for in vivo calcium imaging in freely-behaving mice.

Running Promotes Spatial Bias Independently Of Adult Neurogenesis

This study shows that running promotes spatial navigation strategies in mice, even when adult neurogenesis is blocked, suggesting exercise enhances cognitive flexibility independently of neurogenesis.