Jason S. Snyder

This study shows that chronic electroconvulsive shock in mice impairs hippocampal synaptic function and associative memory, but not object or location memory.

NC4Touch is an open-source rodent touchscreen apparatus that enables affordable, customizable, and high-throughput behavioral testing in mice and rats.

The paper quantifies neuronal birth and loss in the rat dentate gyrus across adulthood, finding that neurogenesis contributes to growth but is offset by neuronal turnover.

This study uses a mouse model to show that early tau pathology in the entorhinal cortex induces morphological changes and neurogenic plasticity in the hippocampus without affecting synaptic strength.

The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.

This study shows that inhibiting adult neurogenesis affects spatial learning differently in male and female rats under stressful conditions, with males showing slower learning and females faster learning in cold water.

The paper investigates long-term potentiation (LTP) at lateral perforant path synapses onto adult-born neurons, finding prolonged development of LTP beyond the traditional critical period.

This study shows that blocking hippocampal neurogenesis in rats reduces activation of the ventral dentate gyrus and causes aversion to delayed rewards.

The paper examines the development and morphology of adult-born neurons in rats, finding they mature over months and have distinct features compared to neonatally-born neurons, contributing to hippocampal plasticity into old age.

The paper shows that neurons born at the peak of development in the dentate gyrus die later in adulthood, while neurons born before or after are stable.

This study shows that adult neurogenesis enhances efficient, nonspecific search strategies in a spatial alternation water maze task, particularly when platform locations alternate.

This study shows that increasing adult neurogenesis in rats reduces activity in developmentally-born dentate granule neurons, supporting an inhibitory role for new neurons in hippocampal function.

This study examines the long-term effects of exercise and memantine on adult neurogenesis in male and female rats, finding sex-specific differences in treatment efficacy.

This study shows that male and female rats without adult neurogenesis can still discriminate local and distal cues in spatial memory tasks.

This study examines the survival and maturation of developmentally-born dentate gyrus neurons, finding they survive early but experience delayed death later, with implications for memory and neurological disorders.

This study shows that running promotes spatial navigation strategies in mice, even when adult neurogenesis is blocked, suggesting exercise enhances cognitive flexibility independently of neurogenesis.