Hang Lyu

Scorpion toxin peptide BMK86-P1 achieves mutation-reversible inhibition of KCNA2 at the cost of reduced efficacy in heteromers and murine neurons

The paper demonstrates that the scorpion toxin BMK86-P1 selectively inhibits KV1.2 homomers but not heteromers, with a mutation reducing its efficacy and altering channel activation.

Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry

This paper develops a method to label and image AIS proteins in living neurons using unnatural amino acids and bioorthogonal click chemistry, demonstrating its application to study NaV1.6 variants.