Author

Juergen Scharner

Cold Spring Harbor LaboratoryORCID 0000-0002-1110-8688Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrian R. KraineriD· 2 shared C. Frank BennettiD· 1 shared Frank RigoiD· 1 shared Kuan‐Ting LiniD· 1 shared Sabrina QiiD· 1 shared Wai Kit MaiD· 1 shared Yun‐Ru LiuiD· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersMolecular Biology

Adrian R. KrainerORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular Therapy — Nucleic AcidsPeer-reviewedMar 12, 2019

Delivery of GalNAc-conjugated splice-switching ASOs to non-hepatic cells through ectopic expression of asialoglycoprotein receptor

Juergen Scharner, Sabrina Qi, Frank Rigo…·Adrian R. Krainer

This study demonstrates that GalNAc-conjugated ASOs can target cancer cells expressing ectopic ASGP-R, improving splice-switching ASO potency in vitro and in tumor models.

29 citations

mouseexperimental assay

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BioinformaticsGenome ResearchPeer-reviewedMar 1, 2018

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma

Kuan‐Ting Lin, Wai Kit Ma, Juergen Scharner…·Adrian R. Krainer

The paper identifies a human-specific switch in AFMID isoforms linked to TP53 mutations and HCC recurrence through splicing changes analyzed in RNA-Seq datasets.

33 citations

humanbulk RNA-seq

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