Circulating extracellular vesicles in lung cancer patients are not enriched in tumor-derived DNA fragments as revealed by whole genome sequencing.
Norbert Moldován, Sandra A.W.M. Verkuijlen, Ymke van der Pol, Leontien Bosch, Jan R.T. van Weering, Idris Bahce, Dirk Michiel Pegtel, Florent C. Mouliere
The paper shows that EV-DNA in lung cancer patients is not enriched in tumor signal compared to plasma cfDNA, with similar fragmentation and tumor content.
bioRxiv · Jul 22, 2022 · PreprintGenomics