Jan R.T. van Weering

Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

This study shows Rab10 maintains Ca2+ homeostasis and protein synthesis to regulate neuropeptide release via DCVs in mouse hippocampal neurons.

Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes

This study shows tomosyns inhibit synaptic depression by binding to VAMP2-containing template complexes and preventing SNAP-25 association, rather than competing with VAMP2 for SNARE complex assembly.

Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

This study shows that SNX4 limits synaptic vesicle docking and release by affecting active zone structure and vesicle density.

SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons

This study shows that tomosyn regulates DCV cargo levels but not exocytosis in neurons, suggesting a role in cargo production rather than release.

Circulating extracellular vesicles in lung cancer patients are not enriched in tumor-derived DNA fragments as revealed by whole genome sequencing.

The paper shows that EV-DNA in lung cancer patients is not enriched in tumor signal compared to plasma cfDNA, with similar fragmentation and tumor content.

Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1

The paper shows that post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1, enhancing release rates through additive mechanisms.

Retrograde transport defects in Munc18-1 null neurons explain abnormal Golgi morphology

This study identifies retrograde transport defects in MUNC18-1 null neurons as the cause of abnormal Golgi morphology and neurodegeneration.

The endosomal protein sorting nexin 4 is a novel synaptic protein

This study identifies SNX4 as a novel synaptic protein through localization and functional analysis in neurons.