Author

Ymke van der Pol

Amsterdam University Medical CentersORCID 0000-0002-3040-5848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:whole-genome sequencing· 3 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Florent C. MouliereiD· 3 shared Norbert MoldovániD· 3 shared Dirk Michiel PegteliD· 2 shared Idris BahceiD· 2 shared Sandra A.W.M. Verkuijlen· 2 shared Alessio MarcozziiD· 1 shared Dàmi Rebergen· 1 shared Dries BoersiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Florent C. MouliereORCID

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Author profile →

3 papers

Recent·Most cited

Nanopore-based consensus sequencing enables accurate multimodal tumor cell-free DNA profiling

Li‐Ting Chen, Myrthe Jager, Dàmi Rebergen, Geertruid Johanna Brink, Tom van den Ende, Willem Vanderlinden, Pauline J. Kolbeck, Marc Pagès-Gallego, Ymke van der Pol, Nicolle J.M. Besselink, Norbert Moldován, Nizar Hami, Wigard P. Kloosterman, Hanneke W.M. van Laarhoven, Florent C. Mouliere, , Jeroen de Ridder

This paper introduces NanoRCS, a method using nanopore sequencing and consensus calling to accurately estimate tumor fractions from cfDNA by analyzing SNVs, CNAs, and fragmentomics.

Genome Research · Apr 1, 2025Peer-reviewedGenomics

Circulating extracellular vesicles in lung cancer patients are not enriched in tumor-derived DNA fragments as revealed by whole genome sequencing.

Norbert Moldován, Sandra A.W.M. Verkuijlen, Ymke van der Pol, Leontien Bosch, Jan R.T. van Weering, Idris Bahce, Dirk Michiel Pegtel, Florent C. Mouliere

The paper shows that EV-DNA in lung cancer patients is not enriched in tumor signal compared to plasma cfDNA, with similar fragmentation and tumor content.

bioRxiv · Jul 22, 2022 · PreprintGenomics

The effect of pre-analytical and physiological variables on cell-free DNA fragmentation.

Ymke van der Pol, Norbert Moldován, Sandra A.W.M. Verkuijlen, Jip Ramaker, Dries Boers, Wendy Onstenk, Johan de Rooij, Idris Bahce, Dirk Michiel Pegtel, Florent C. Mouliere

This study examines how pre-analytical and physiological factors affect cfDNA fragmentation patterns and fragment-end sequences using whole genome sequencing.

Clinical Chemistry · Feb 9, 2022Peer-reviewedGenomics