Author

Ian Y. Yen

University of TorontoORCID 0000-0002-1122-4443Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

P. Lynne HowelliD· 3 shared Gregory B. WhitfieldiD· 2 shared Lori L. BurrowsiD· 2 shared Yves V. BruniD· 2 shared Courtney K. EllisoniD· 1 shared John L. RubinsteiniD· 1 shared Taylor J. EllisoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

P. Lynne HowellORCID

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3 papers

Recent·Most cited

Reversible biological motion with unidirectional catalysis through inversion of ATPase orientation

Gregory B. Whitfield, Ian Y. Yen, Lori L. Burrows, P. Lynne Howell, Yves V. Brun

The paper shows how the Tad motor ATPase CpaF achieves reversible pilus motion through physical inversion of its orientation, using a single unidirectional catalytic cycle.

bioRxiv · Feb 25, 2026 · PreprintMicrobiology

FimX regulates type IV pilus localization via the Pil-Chp chemosensory system in Acinetobacter baylyi

Taylor J. Ellison, Ian Y. Yen, P. Lynne Howell, Courtney K. Ellison

This paper identifies FimX as a regulator of T4P positioning in Acinetobacter baylyi through interaction with the Pil-Chp chemosensory system.

Molecular Biology of the Cell · Jul 30, 2025Peer-reviewedMicrobiology

Coordinated conformational changes in the Tad pilus ATPase CpaF facilitate a rotary mechanism of catalysis

Ian Y. Yen, Gregory B. Whitfield, John L. Rubinstein, Lori L. Burrows, Yves V. Brun, P. Lynne Howell

The paper determines cryo-EM structures of CpaF in different conformations and proposes a rotary mechanism of catalysis for Tad pilus assembly and disassembly.

Nature Communications · Apr 23, 2025Peer-reviewedMicrobiology