Yves V. Brun

Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota

This paper analyzes the evolution and functional diversification of the WhiG sigma factor in Actinomycetota, revealing two distinct clades with different regulatory mechanisms and expanded biological roles.

MreB is dispensable for viability but critical for rod shape, motility and biofilm fitness in Pseudomonas aeruginosa

In situ Architecture of the Tad Pilus Machine in Caulobacter crescentus

This study uses cryo-ET and subtomogram averaging to determine the in situ architecture of the Tad pilus machine in Caulobacter crescentus, revealing its assembly intermediates and structural framework.

Reversible biological motion with unidirectional catalysis through inversion of ATPase orientation

The paper shows how the Tad motor ATPase CpaF achieves reversible pilus motion through physical inversion of its orientation, using a single unidirectional catalytic cycle.

Stimulation of the Caulobacter crescentus surface sensing pathway by deletion of a specialized minor pilin-like gene

This study identifies CpaL as a mechanosensory protein involved in pilus-mediated surface sensing in Caulobacter crescentus, showing that its deletion increases surface adhesion through enhanced holdfast production.

Functional specialization of the subdomains of a bactofilin driving stalk morphogenesis in Asticcacaulis biprosthecum

This study investigates the functional roles of BacA subdomains in stalk morphogenesis in A. biprosthecum, showing that polymerization, membrane association, and interactions with SpmX are essential for proper stalk formation.

Phenotypic plasticity in bacterial elongation among closely related species

The paper reveals diverse cell elongation mechanisms in closely related bacterial species using fluorescent D-amino acids and shows phenotypic plasticity in elongation complexes.

Coordinated conformational changes in the Tad pilus ATPase CpaF facilitate a rotary mechanism of catalysis

The paper determines cryo-EM structures of CpaF in different conformations and proposes a rotary mechanism of catalysis for Tad pilus assembly and disassembly.

The vprAB-ompV-virK operon of Vibrio cholerae senses antimicrobial peptides and activates the expression of multiple resistance systems

This paper identifies a specialized operon in Vibrio cholerae that senses antimicrobial peptides and activates multiple resistance systems, including efflux pumps and outer membrane modifications.

Generalists in a Specialist World: Vibrio-Phages with Broad Host Range

This study examines broad-host-range Vibrio phages, identifying genetic features and ecological trade-offs that influence their host range and environmental distribution.