β-amyloid-driven synaptic depression requires PDZ protein interaction at AMPA-receptor subunit GluA3
Niels R. Reinders, Sophie J. F. van der Spek, Remco V. Klaassen, Karin J. Koymans, Ka Wan Li, August Benjamin Smit, Helmut W. H. G. Kessels
This study shows that β-amyloid oligomers cause synaptic depression by removing GluA3-containing AMPARs from synapses, requiring PDZ protein interaction.
bioRxiv · Oct 3, 2021 · PreprintNeuroscience