Ultra-stable insulin-glucagon fusion protein exploits an endogenous hepatic switch to mitigate hypoglycemic risk
Nicolás Varas, Mark A. Jarosinski, Yen‐Shan Chen, Chun‐Lun Ni, Rachel Grabowski, Ningwen Tai, Raimund I. Herzog, Faramarz Ismail‐Beigi, Yanwu Yang, Alan D. Cherrington, Michael Aaron Weiss
This paper develops an ultra-stable insulin-glucagon fusion protein that exploits a hepatic glucose switch to reduce hypoglycemic risk in diabetes, showing improved stability and glycemic control in rats.
ACS Pharmacology & Translational Science · Aug 14, 2025Peer-reviewedBioengineering