Yen‐Shan Chen

This paper develops an ultra-stable insulin-glucagon fusion protein that exploits a hepatic glucose switch to reduce hypoglycemic risk in diabetes, showing improved stability and glycemic control in rats.

The paper generates a transgenic mouse model expressing human SRY to study its role in sex determination and DSD, identifying functional domains and mutations.

The paper investigates inherited and de novo mutations in SRY causing sex reversal, showing that Y127F preserves transcriptional activity while Y127C leads to proteasomal degradation.

The paper describes a novel SRY mutation causing 46, XY sex reversal, showing its partial function and phenotypic effects in a family.