Cell BiologybioRxivPreprint
A Nerve-Dependent NGF Receptor Switch Controls Corneal Epithelial Renewal In Neurotrophic Keratopathy
Arif Hussain, Kiana Tajdaran, Ramkumar Katturajan…·Konstantin Feinberg
The paper shows that denervation shifts NGF receptor signaling in corneal epithelial stem cells from TrkA-AKT to p75NTR-JNK, explaining limited rhNGF efficacy in neurotrophic keratopathy and suggesting receptor-selective modulation as a therapy.
DOI 10.64898/2026.06.30.735622