Author

Jamie M. O’Sullivan

Royal College of Surgeons in IrelandORCID 0000-0002-1162-8739Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

James S. O’DonnelliD· 2 shared Roger J. S. PrestoniD· 2 shared Aisling M. RehilliD· 1 shared Alain Chion· 1 shared Anna E. LedwithiD· 1 shared Anne‐Marije HulshofiD· 1 shared Annie M. CurtisiD· 1 shared Bernd JilmaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

James S. O’DonnellORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 9, 2026

Type 2B VWD substitutions trigger enhanced macrophage-mediated clearance that is attenuated by the BT200 aptamer

Alain Chion, Ciara Byrne, Anne‐Marije Hulshof…·James S. O’Donnell

This study shows type 2B VWD variants bind more strongly to macrophages via LRP1 and MGL receptors, and this binding is reduced by the BT200 aptamer.

DOI 10.64898/2026.09.07.749810

humanprotein structure

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ImmunologyScience AdvancesPeer-reviewedMar 7, 2025

Trained Immunity Causes Myeloid Cell Hypercoagulability

Aisling M. Rehill, Seán McCluskey, Anna E. Ledwith…·Roger J. S. Preston

This study identifies enhanced myeloid cell prothrombotic activity as a novel consequence of trained immunity, mediated by epigenetic changes and acid sphingomyelinase.

13 citationstop 5%

mouseproteomics

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