Roger J. S. Preston

This study shows type 2B VWD variants bind more strongly to macrophages via LRP1 and MGL receptors, and this binding is reduced by the BT200 aptamer.

This study identifies enhanced myeloid cell prothrombotic activity as a novel consequence of trained immunity, mediated by epigenetic changes and acid sphingomyelinase.

This study identifies TF-mediated thrombogenicity in colitogenic CD4+ T cells and shows APC signalling reduces their procoagulant activity in IBD.

This study shows that sepsis-induced NET formation depends on MYD88 but not GSDMD or PAD4, revealing distinct pathways for NET formation in different conditions.