Annie M. Curtis

Metabolic Reprogramming of Human Macrophages Drives the Formation of Hybrid M1/M2 Pro-Regenerative Extracellular Vesicles

This study shows that metabolic reprogramming of human macrophages using DASA-58 generates hybrid M1/M2 extracellular vesicles with pro-regenerative properties that enhance angiogenesis and osteogenesis.

Trained Immunity Causes Myeloid Cell Hypercoagulability

This study identifies enhanced myeloid cell prothrombotic activity as a novel consequence of trained immunity, mediated by epigenetic changes and acid sphingomyelinase.

EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS

This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.

Post-Transcriptional Circadian Regulation in Macrophages Organizes Temporally Distinct Immunometabolic States

The paper shows that circadian regulation in macrophages involves extensive post-transcriptional control of the proteome, influencing metabolic states and immune functions.