Author

Piet Ost

Ghent University HospitalORCID 0000-0002-2203-4848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 1 Assay:GWAS summary statistics· 1 Research Focus:polygenic risk· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam Stuart KibeliD· 2 shared Alicja WolkiD· 2 shared Ana Isabel VegaiD· 2 shared Anders Martin DaleiD· 2 shared Barry S. RosensteiniD· 2 shared Børge Grønne NordestgaardiD· 2 shared Cezary CybulskiiD· 2 shared Christopher J. LogothetisiD· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Adam Stuart KibelORCID

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3 papers

Recent·Most cited

Germline polygenic score for prostate cancer aggressiveness

George Jing Xu, Roshan A. Karunamuni, Anna M. Dornisch, Charles A. Brunette, Morgan E. Danowski, Heena Desai, Daniel R. Dochtermann, Isla P. Garraway, Richard L. Hauger, Adam Stuart Kibel, Julie Ann Lynch, Saiju Pyarajan, Brent Shane Rose, Craig Carl Teerlink, Ole A. Andreassen, , Tyler M. Seibert

This paper develops a germline polygenic score (PRSagg) to predict prostate cancer aggressiveness and validates it across multiple datasets.

medRxiv · May 13, 2026 · PreprintGenetic & Genomic Medicine

Prostate cancer risk stratification improved across multiple ancestries with new polygenic hazard score

Minh‐Phuong Huynh‐Le, Roshan A. Karunamuni, Chun Chieh Fan, Asona J. Lui, Wesley K. Thompson, Marı́a Elena Martı́nez, Rosalind A. Eeles, Zsofia Kote‐Jarai, Kenneth Ross Muir, Artitaya Lophatananon, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Grönberg, David Edgar Neal, , Canary PASS Investigators

The paper improves prostate cancer risk stratification across multiple ancestries using a new polygenic hazard score with additional SNPs, showing higher hazard ratios and positive predictive value for clinically significant prostate cancer.

medRxiv · Aug 14, 2021 · PreprintGenetic & Genomic Medicine

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen, Christophe Ghysel, J Ampe, Piet Ost, Wim Demey, Lucien Hoekx, Dirk L. A. L. Schrijvers, Barbara Anna Henk Brouwers, Willem Lybaert, Els Grieta Everaert, Daan Joost De Maeseneer, Michiel Hendrik Strijbos, , Johan Lindberg

This study profiles cell-free DNA in metastatic prostate cancer patients, identifying genomic alterations, microsatellite instability, and clonal hematopoiesis as potential biomarkers.

Genome Medicine · Nov 19, 2018Peer-reviewedGenomics