Author

Usha Singh

Janssen Research & Development (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alessio CrippaiD· 1 shared Alexander S. BrandisiD· 1 shared Alpha A. LeeiD· 1 shared Anastassija Kotsalaynen· 1 shared Andre Schutzer GodoyiD· 1 shared Bram De LaereiD· 1 shared Briana Lynn McGoverniD· 1 shared Charles W.E. TomlinsoniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alessio CrippaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

Alpha A. Lee, Isabelle Amick, Jasmin Cara Aschenbrenner, Haim Michael Barr, Jared Benjamin, Alexander S. Brandis, Galit Cohen, Randy Diaz-Tapia, Shirly Duberstein, Jessica Dixon, David Cousins, M. Fairhead, D. Fearon, James Frick, James R. Gayvert, , Max Winokan

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

bioRxiv · Aug 19, 2024 · PreprintMicrobiology

Sensitive detection of copy number alterations in samples with low circulating tumor DNA fraction.

Markus Mayrhofer, Rebecka Bergström, Venkatesh Chellappa, Anastassija Kotsalaynen, Sarath Kumar Murugan, Alessio Crippa, Bram De Laere, Karen A. Urtishak, Karina Dalsgaard Sørensen, Kavita Garg, Usha Singh, Martin Eklund, Henrik Grönberg, Johan Lindberg

The paper introduces Jumble, an algorithm that improves the sensitivity of detecting copy number alterations in low ctDNA samples, achieving detection limits of 1-2% for amplifications and 4-8% for deletions.

medRxiv · May 4, 2024 · PreprintGenetic & Genomic Medicine