Amanda D. Clark

The paper evaluates changes in glia-neuron communication in 3xTg-AD mice hippocampus at 6 and 12 months, finding increased dysregulation and 23 AD-associated ligand-receptor pairs.

The paper uses long-read RNA sequencing to analyze C57BL/6J mouse brain isoform expression and identifies region- and sex-specific alternative splicing patterns.

The paper identifies altered glia-neuron communication in Alzheimer's disease using snRNA-seq, revealing dysregulation of WNT, p53, and NFkB signaling in inhibitory neurons.

The paper identifies drug repurposing candidates for low-survival cancers by prioritizing drugs that reverse disease-associated gene signatures using three methods.

The paper analyzes SETBP1 gene expression and transcription factor activity across 31 human tissues using GTEx data, identifying tissue-specific patterns and providing a web tool for exploration.

CoSIA provides a framework for cross-species transcriptomic comparison of non-diseased RNA-seq data across multiple species.

The paper identifies sex-biased adverse event drug targets and metabolism genes, showing their sex-specific gene expression and regulatory networks.

The paper presents a chromosome-level genome assembly for Sceloporus undulatus and evaluates its utility for genomic analysis across related species.