Tabea M. Soelter

The paper identifies therapeutic drugs and targets for SETBP1-HD by integrating regulatory analysis and signature reversion across transcriptomic datasets.

The paper evaluates changes in glia-neuron communication in 3xTg-AD mice hippocampus at 6 and 12 months, finding increased dysregulation and 23 AD-associated ligand-receptor pairs.

The paper identifies cell-type-specific alternative splicing changes in the cerebral cortex and kidney of Setbp1S858R mice, with implications for Schinzel-Giedion Syndrome.

The paper identifies altered glia-neuron communication in Alzheimer's disease using snRNA-seq, revealing dysregulation of WNT, p53, and NFkB signaling in inhibitory neurons.

The paper compares six copy number-based chromosomal instability (CIN) metrics across 33 TCGA cancer datasets to assess their correlation with tumor type, clinical characteristics, and patient sex.

This study uses snRNA-seq to analyze gene expression and regulatory changes in atypical SGS mice, revealing cell-type-specific effects of SETBP1 variants in the cerebral cortex and kidney.